Comprehensive Scoliosis Care
for Children and Adults

The ScoliSMART Approach
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At ScoliSMART Clinics, we offer the most comprehensive scoliosis treatment program ever created — available to both children (6-17) and adults (18+) with idiopathic scoliosis. We strive to treat the whole scoliosis condition, not just the curve. For children, this means getting back to being a kid — not a condition. For adults, this means addressing the underlying causes of chronic scoliosis pain.

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Is Scoliosis Hereditary, Genetic or Environmental?

A sideways-curving spine is the most troubling aspect of scoliosis, but it is not the real problem. To figure out what actually causes scoliosis, scientists must look beyond the curve.

We now know that spinal curvature stems from a miscommunication between the brain and muscles that support the spine. A child’s postural control centers fail to tell the muscles how to properly respond to gravity, so instead of growing straight the spine becomes curved. But why aren’t those messages being sent? More and more clinical data is pointing toward specific genomic functional variant patterns, which affect neurotransmitter and hormone production/metabolism.

mom-daughter-scoliosisIt is a question with which doctors continue to grapple. Is scoliosis genetic? Hereditary? Caused by environmental factors? Most of the time there is no clear answer, and that is what makes scoliosis such a difficult condition to treat.

An increasing number of research studies indicate idiopathic scoliosis is likely a combination of functional genomic variants, which decrease the performance of specific genetic combinations that make key proteins, enzymes, neurotransmitters, and hormones. Without normal production, the levels of each falls into a pattern which alters your brain’s “postural memory.”

Are You Born with Scoliosis?

In about 20 percent of cases, the scoliosis causes are obvious; birth defects, bone damage, and neuromuscular disorders can all cause spinal curves to form, but they are a small minority. More than eight in 10 scoliosis cases are idiopathic, which means they have no known cause.

Through decades of research, scientists have been able to piece together a number of observations and findings about adolescent idiopathic scoliosis; thus far, however, those findings have defied any unified theory to explain why one child’s curve progresses rapidly while another child’s curve requires no medical attention at all.

“Adolescent idiopathic scoliosis probably results from a combination of genetic and environmental factors,” says the National Institute of Health. “Studies suggest that the abnormal spinal curvature may be related to hormonal problems, abnormal bone or muscle growth, nervous system abnormalities, or other factors that have not been identified.”

Is Scoliosis a Genetic Disorder? Is Scoliosis Genetically Inherited?

Strong evidence suggests that scoliosis runs in families. Nearly a third of patients with adolescent idiopathic scoliosis have a family history of the condition, and first-degree relatives of scoliosis patients have an 11 percent chance of developing it themselves.

29% of the daughters and only 9% of sons of a parent with scoliosis are likely to develop the condition, suggesting specific genomic variant groups (e.g. COMT variants) involving estrogen may be heavily involved with the production, metabolism, and breakdown of estrogen. This may lead to “estrogen signaling dysfunction” and discoordination of hormone levels as the patient enters into pre-teen growth spurts leading up to the onset of menstruation.

Related: Scoliosis and Pregnancy: What You Need to Know

“It is possible that genetic factors may be involved in specific aspects of scoliosis, including the shape of a scoliosis curve and the risk for curve progression,” said scoliosis specialist Christopher R. Good, M.D., in the Journal of the Spinal Research Foundation. “A number of population studies have documented that scoliosis runs within families and that there is a higher prevalence of scoliosis among relatives of patients with scoliosis than within the general population.”

The numbers support the theory that scoliosis is hereditary, or passed down from family members — but does that necessarily mean it is genetic?

To answer that question, it is important to understand the difference between genetic and hereditary. Most people use them synonymously, and in many cases they are, but there are subtle differences. A trait can be hereditary without being genetic; cultural characteristics, for example, are passed down through families but are not connected to genes, and genetic traits are not always hereditary. Consider cancer, which arises from mutant genes but in most cases is not inherited from one’s parents.

By examining the inheritance patterns of scoliosis, scientists have concluded the condition is genetic as well as hereditary. In fact, only recently the doctors at ScoliSMART Labs have discovered 28 genomic functional variant groups directly associated with idiopathic scoliosis. This information could be vital to predicting the onset of idiopathic scoliosis and likelihood of severe progression, and even possibly prevent the condition with highly targeted nutrient therapies.

“Researchers suspect that many genes are involved in adolescent idiopathic scoliosis,” says the National Institute of Health. “Some of these genes likely contribute to causing the disorder, while others play a role in determining the severity of spinal curvature and whether the curve is stable or progressive. Although many genes have been studied, few clear and consistent genetic associations with adolescent idiopathic scoliosis have been identified.”

Is Scoliosis Environmental in Nature?

When studying what causes scoliosis, hereditary factors can provide a lot of insight — but they also raise as many questions as they answer.

For example, if scoliosis is hereditary, why does it also crop up in children with no family history of the condition? Another oddity researchers have noted is the condition seems to have variable effects within each generation. A mother with a mild curve might have a daughter with a severe one, or the scoliosis might skip a generation entirely.

Scientists have explained these anomalies by acknowledging that environmental factors probably contribute to differences in scoliosis development, progression, and age at detection. Consider that at least 4 percent of scoliosis curves progress to the threshold for surgery, yet only 1 percent of patients have a high genetic risk of severe curvature. If genes are a factor in only 1 percent of cases, environmental factors must account for the severity in the other 3 percent.

But identifying what those factors are is tricky. Studies have ruled out the theory that the curves are caused by specific behaviors such as slouching or carrying a heavy backpack. They have also found no link between scoliosis and living in an industrialized area.

Understanding what causes scoliosis is like hitting a moving target. It is not a fixed deformity but a dynamic process that appears to spring from a combination of different factors. The more we study it, however, the better equipped we become to effectively treat the condition.

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