1. The orgins of AIS is most likely linked to a genetic defect of the central control or processing by the central nervous system (Pons and hind brain) that affects the growing spine.

2. It appears that factors that pre-dispose/initiate AIS are separate from the factors that drive curve progression.

3. The consensus is that RASO results largely from biomechanical spinal growth modulation.

4. The NOTOM concept was formulated to explain why adolscent girls are more susceptible than boys to curve progression. Based on the timing of adolescent growth spurts (earlier in females) in relation to the timing of postural maturity (similar in boys and girls).