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Mechanical spinal growth modulation (AKA: The vicious cycle)

This theory is the most supported and generally accepted theory. Purposed by Dr. Ian Stokes (one of my personal favorites) as early as 1996, the biomechanical spinal growth modulation suggests spinal imbalance through gravity and continuous muscle action leads to asymmetric loading of the vert. growth plates and hence asymmetric growth via the Heuter-Volkmann prinicple.

Perdriolle reports that the onset of AIS occurs as a result of a mechanical process termed "geometic torsion of the vertebral bodies" but worsening was caused by deformation of the vert. bodies.

Stokes developed a 2-D mathematical simulation of the lumbar vertebra (not the discs) and tested whether the calculated loading asymmertry created by muscles in a spine with scoliosis could explain the observed rate of scoliosis. The results were consistent with the clinical observations.

Stokes' "Vicious Cycle"
1. Pre-existing scoliosis curve of unknown etiology (probably genetic underdevelopment of the neurological postural control centers in the CNS from the current knowledge privided by Axial bio-tech (developers of Scoliscore).
2. Putative neuromuscular dysfunction with the most physiological strategy causing loads more the concavity at the apex of the curve.
3. Neuro-muscular determined left-right asymmetric loading of vert bodies sustained over a substantial portion of the day.
4. Vertebral body growth plates (sensitive to altered asymmetic compression) with mechanically modulated alteration of growth leads to AIS curve progression
*** Different individual adopt different neuromuscular strategies which explains curve patterns and varied progression rates.